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Therefore, despite standard treatment, tumor recurrence occurs in many patients, which is mainly due to the cancer cells' ability to activate survival pathways and develop resistance to chemotherapy and radiation therapy

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Additional roles of ALDH2: In addition to breaking down alcohols, ALDHD also metabolizes:[ref] Retinol (vitamin A) Bile acids lipid peroxidation products neurotransmitter metabolites Studies link genetic variants in ALDH2 to increased risk of Alzheimer’s disease, possibly due to the decreased ability to break down lipid peroxidation products in the brain